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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Approximately 15–25% of recognized pregnancies end in miscarriage. However, many miscarriages often occur before a woman even knows she is pregnant.
Human stomach acid is strong enough to dissolve small pieces of metal such as razor blades or staples.
The heart is located in the center of the chest, with part of it tipped slightly so that it taps against the left side of the chest.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.