This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Which of the following numbers could be the therapeutic index (TI) of a drug for which there is the ... (Read 23 times)

chads108

  • Hero Member
  • *****
  • Posts: 507
on: Jul 23, 2018
Which of the following numbers could be the therapeutic index (TI) of a drug for which there is the greatest possibility of toxicity?
 
  a. 2
  b. 1
  c. 5
  d. 10

Question 2

Which substance produces a response equal to or greater than the effects of an endogenous chemical in the body?
 
  a. Competitive inhibitor
  b. Noncompetitive inhibitor
  c. Antagonist
  d. Agonist


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

cuttiesgirl16

  • Sr. Member
  • ****
  • Posts: 345
Reply #1 on: Jul 23, 2018
Answer to Question 1

ANS: B
A drug's TI expresses the relative safety of a drug. TI relates the dose of a drug required to pro-duce a desired effect to that producing an adverse or toxic response. Drugs with a high TI are said to be safe (i.e., to have a wide margin of safety). Those with a low TI are relatively unsafe and have the narrowest margin of safety, therefore the greatest possibility of toxicity.

Answer to Question 2

ANS: D
Agonists combine with receptors to initiate events; that is, they have intrinsic activity that is produced by two different mechanisms. Agonist I drugs bind to the same site as an endogenous substance (e.g., neurotransmitter) to produce a similar response. The response usually equals, or is greater than, that of the endogenous substance. Agonist II drugs bind to different extracellular sites, with no response produced solely in the presence of the agonist. However, an enhanced re-sponse is generated when an existing endogenous substance also binds to its site.


chads108

  • Member
  • Posts: 507
Reply 2 on: Jul 23, 2018
Excellent

dantucker

  • Member
  • Posts: 346
Reply 3 on: Yesterday
Great answer, keep it coming :)

« previous next »
 

Did you know?

No drugs are available to relieve parathyroid disease. Parathyroid disease is caused by a parathyroid tumor, and it needs to be removed by surgery.

Did you know?

People often find it difficult to accept the idea that bacteria can be beneficial and improve health. Lactic acid bacteria are good, and when eaten, these bacteria improve health and increase longevity. These bacteria included in foods such as yogurt.

Did you know?

In Eastern Europe and Russia, interferon is administered intranasally in varied doses for the common cold and influenza. It is claimed that this treatment can lower the risk of infection by as much as 60–70%.

Did you know?

During pregnancy, a woman is more likely to experience bleeding gums and nosebleeds caused by hormonal changes that increase blood flow to the mouth and nose.

Did you know?

The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.

Subcutaneous drug administration: (d) the needle is removed and the puncture site is covered with an Subcutaneous drug administration: (d) the needle is removed and the puncture site is covered with an
Drug Actions at Binding Sites Drug Actions at Binding Sites
Organizing Drug Information by Pharmacologic Classification Organizing Drug Information by Pharmacologic Classification
The Need for Drug Control The Need for Drug Control
How to calculate the gain and loss gene numbers with low bootstrap of phylogenetic tree? How to calculate the gain and loss gene numbers with low bootstrap of phylogenetic tree?
A buffer solution is prepared using 0.5 moles of a weakly basic drug and an unknown quantity of ... A buffer solution is prepared using 0.5 moles of a weakly basic drug and an unknown quantity of ...
Video: Mendel's pea plant, Pisum sativum experimental

For a complete list of videos, visit our video library