Answer to Question 1
1,2,4,5
Rationale 1: Pulmonary irritants such as smoking should be avoided as drug effectiveness may be decreased.
Rationale 2: Sedation may occur if this drug is used concurrently with alcohol.
Rationale 3: The drug works in about 15 to 30 minutes.
Rationale 4: Grapefruit juice may raise serum levels of dextromethorphan and cause toxicity.
Rationale 5: Slurring speech may indicate CNS toxicity is occurring.
Global Rationale: Pulmonary irritants such as smoking should be avoided as drug effectiveness may be decreased. Sedation may occur if this drug is used concurrently with alcohol. Grapefruit juice may raise serum levels of dextromethorphan and cause toxicity. Slurring speech may indicate CNS toxicity is occurring. The drug works in about 15 to 30 minutes.
Answer to Question 2
4
Rationale 1: This is a barrier to the distribution of medications.
Rationale 2: This is a barrier to the distribution of medications.
Rationale 3: This is a barrier to the distribution of medications.
Rationale 4: There is no blood-lung barrier.
Global Rationale: Three important organs contain anatomic barriers that prevent some drugs from gaining access. These are the brain, the placenta, and the testes. The cellular barriers only allow fat-soluble substances to cross. These are the blood-barrier, blood-placental barrier, and the blood-testicular barrier. There is no blood-lung barrier for the distribution of medication.
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