The nurse is administering the first dose of irinotecan ...

[Kikoku]

The nurse is administering the first dose of irinotecan (Camptosar) to a patient on the oncology unit. Shortly after the infusion is complete, the patient begins to complain of severe diarrhea.
 
  The nurse understands that the diarrhea is caused by
  a. excessive cholinergic stimulation of the gastrointestinal tract.
  b. stimulation of H2 receptors.
  c. excessive water being drawn into the gastrointestinal tract.
  d. bowel obstruction.

Question 2

A patient with chronic lymphocytic leukemia is being started on oral cyclophosphamide. The nurse should instruct the patient to take the drug:
 
  1. with food.
  2. on an empty stomach.
  3. 2 hours before a meal.
  4. before bed.

[paavo]

Answer to Question 1

ANS: A
Early diarrhea occurs within 24 hours of administration of irinotecan because of excessive cholinergic stimulation of the gastrointestinal tract.
The medication does not cause excessive stimulation of H2 receptors, which would not cause diarrhea in any case.
Although one etiology of diarrhea is excessive waters drawn into the GI tract, this is not the etiology of the diarrhea caused by irinotecan.
Bowel obstruction is unlikely with irinotecan.

Answer to Question 2

Correct Answer: 1

[Kikoku]

TY

[paavo]

You're welcome