A male patient with hepatitis C will begin triple drug therapy with pegylated interferon alfa 2a (Pegasys), ribavirin (Ribasphere), and boceprevir (Victrelis). The patient tells the nurse that his wife is pregnant. What will the nurse tell him?
a. Boceprevir is contraindicated in males whose partners are pregnant.
b. He should use a barrier contraceptive when having sex.
c. He should use dual drug therapy with pegylated interferon alfa and ribavirin only.
d. This combination drug therapy is safe for him to use.
Question 2
A patient has a positive test for hepatitis C and is admitted to the hospital. The admission laboratory tests reveal a normal ALT, and a liver biopsy is negative for hepatic fibrosis and inflammation. The nurse will prepare this patient for:
a. dual therapy with pegylated interferon alfa and ribavirin.
b. no medication therapy at this time.
c. pegylated interferon alfa only until ALT levels are elevated.
d. triple drug therapy with pegylated interferon alfa, ribavirin, and boceprevir.
Effect of pH on drug absorption: (a) a weak acid such as aspirin (ASA) is in a nonionized form in an
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