Answer to Question 1
Correct Answer: 1,2
Rationale 1: Symptoms of osteonecrosis of the jaw, which is a possible adverse effect of biphosphonate therapy, include jaw pain and swelling.
Rationale 2: Symptoms of osteonecrosis of the jaw, which is a possible adverse effect of biphosphonate therapy, include loose teeth.
Rationale 3: Elevated blood pressure is not a symptom of osteonecrosis of the jaw.
Rationale 4: Oral lesions are not symptoms of osteonecrosis of the jaw.
Rationale 5: Difficulty swallowing is not a symptom of osteonecrosis of the jaw.
Global Rationale: Symptoms of osteonecrosis of the jaw, which is a possible adverse effect of biphosphonate therapy, include jaw pain and swelling and loose teeth. Elevated blood pressure, oral lesions, and difficulty swallowing are not symptoms of osteonecrosis of the jaw.
Answer to Question 2
Correct Answer: 1,2,3
Rationale 1: Adverse effects of colchicine (Colcrys) include nausea and vomiting.
Rationale 2: Adverse effects of colchicine (Colcrys) include abdominal pain.
Rationale 3: Adverse effects of colchicine (Colcrys) include diarrhea.
Rationale 4: Constipation is not an adverse effect of colchicine (Colcrys).
Rationale 5: Muscle pain is not an adverse effect of colchicine (Colcrys).
Global Rationale: The most significant adverse effects of colchicine are GI related and these may occur in up to 80 of patients. Adverse effects include nausea, vomiting, abdominal pain, anorexia, and diarrhea. Constipation and muscle pain are not adverse effects of cholchicine.