Author Question: A client with Cushing syndrome is prescribed ketoconazole (Nizoral). What should the nurse explain ... (Read 18 times)

jjjetplane · **on:** Jul 23, 2018

A client with Cushing syndrome is prescribed ketoconazole (Nizoral). What should the nurse explain as the reason for this medication?

1. This medication will prevent infections.
2. Cushing syndrome is caused by an infection of the adrenal glands, and the medication will reverse the disease process.
3. This drug blocks the formation of glucocorticoids, lowering their level in your blood.
4. This has been prescribed because you have a fungal infection.

Question 2

Which assessment finding would be associated with a client requiring mineralocorticoid replacement therapy?

1. Respiratory rate of 13 breaths per minute
2. Oral temperature of 100.0F
3. Pulse of 48 beats per minute
4. Blood pressure of 78/58

Cnarkel · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

Correct Answer: 3
Rationale 1: This is not the reason this medication is prescribed for a client with Cushing syndrome.
Rationale 2: Cushing syndrome is not caused by an intra-adrenal infection.
Rationale 3: Ketoconazole rapidly blocks the synthesis of glucocorticoids, lowering serum levels. It is considered an antiadrenal agent and is the drug of choice for clients with Cushing disease needing long-term therapy.
Rationale 4: This is not the reason this medication is prescribed for a client with Cushing syndrome.
Global Rationale: Ketoconazole rapidly blocks the synthesis of glucocorticoids, lowering serum levels. It is considered an antiadrenal agent and is the drug of choice for clients with Cushing disease needing long-term therapy. It does not prevent or treat infection. Cushing syndrome is not caused by infection. The patient is not receiving the medication for a fungal infection, however it is used for that purpose as well.

Answer to Question 2

Correct Answer: 4
Rationale 1: Respiratory rate is not affected by the lack of aldosterone that leads to the need for mineralocorticoid replacement therapy.
Rationale 2: Body temperature is not affected by the lack of aldosterone that leads to the need for mineralocorticoid replacement therapy.
Rationale 3: The pulse rate is more likely to rise in a client requiring mineralocorticoid replacement therapy.
Rationale 4: Clients requiring mineralocorticoid therapy typically have a lack of aldosterone. Aldosterone is the primary hormone regulating sodium and potassium in the body. Losses of aldosterone generally result in a drop in blood pressure and a rise in pulse.
Global Rationale: Clients requiring mineralocorticoid therapy typically have a lack of aldosterone. Aldosterone is the primary hormone regulating sodium and potassium in the body. Losses of aldosterone generally result in a drop in blood pressure and a rise in pulse. The pulse rate is more likely to rise in this client. Respirations and body temperature are not directly affected.