Answer to Question 1
Correct Answer: 1,2
Rationale 1: Intravenous corticosteroids may be ordered to treat acute hyperthyroid states because they block the conversion of T4 to T3 in peripheral tissues.
Rationale 2: Severe hyperthyroid states create high levels of stress that deplete adrenal corticosteroids in the body, and the administration of replacement doses is necessary.
Rationale 3: Steroids do not reduce the TSH level.
Rationale 4: Steroids are not used to maintain the blood pressure in thyroid storm.
Rationale 5: Steroids are not used to stabilize the heart rate in thyroid storm.
Global Rationale: Intravenous corticosteroids may be ordered to treat acute hyperthyroid states because they block the conversion of T4 to T3 in peripheral tissues. Severe hyperthyroid states create high levels of stress that deplete adrenal corticosteroids in the body, and the administration of replacement doses is necessary. Steroids do not reduce TSH level or maintain blood pressure. They are not used to stabilize heart rate.
Answer to Question 2
Correct Answer: 1,2
Rationale 1: Propylthiouracil (PTU) is used to treat hyperthyroidism.
Rationale 2: Methimazole (Tapazole) is used to treat hyperthyroidism.
Rationale 3: Propranolol (Inderal) is not used to treat hyperthyroidism.
Rationale 4: Esmolol (Brevibloc) is not used to treat hyperthyroidism.
Rationale 5: Metoprolol (Toprol) is not used to treat hyperthyroidism.
Global Rationale: Both prophylthiouracil and methimazole are used to treat hyperthyroidism. The other drugs are not indicated for this application, but are used in the treatment of thyroid storm.