Answer to Question 1
Correct Answer: 1
Rationale 1: They do contain substances from bacteria that can kill cancer cells.
Rationale 2: They do not contain substances from plants.
Rationale 3: They do not contain substances from viruses.
Rationale 4: They do not contain substances from hormones.
Global Rationale: The antibiotic antineoplastics contain substances from bacteria (not plants, viruses, or hormones) that have the ability to kill cancer cells.
Answer to Question 2
Correct Answer: 1
Rationale 1: They must be given intravenously, or through direct instillation via a catheter into a body cavity or organ.
Rationale 2: Their adverse effects are similar.
Rationale 3: Their dose-limiting toxicities are similar.
Rationale 4: Their mechanisms of action are similar.
Global Rationale: Unlike the alkylating agents, however, all the antitumor antibiotics must be administered IV or through direct instillation via a catheter into a body cavity or organ. Adverse effects, dose-limiting toxicities, and mechanisms of action are similar.