Answer to Question 1
Correct Answer: 2,3,4,5
Rationale 1: Ampicillin is not a pregnancy category D drug.
Rationale 2: Minocycline is a pregnancy category D drug.
Rationale 3: Neomycin is a pregnancy category D drug.
Rationale 4: Streptomycin is a pregnancy category D drug.
Rationale 5: Doxycycline is a pregnancy category D drug.
Global Rationale: Some anti-infectives are pregnancy category D, such as minocycline, doxycycline, neomycin, and streptomycin.
Answer to Question 2
Correct Answer: 3
Rationale 1: Vaginal discharge is not a sign of nosocomial infection.
Rationale 2: Vaginal discharge is not a sign of penicillin overdose.
Rationale 3: Superinfections occur when organisms normally present in the body are destroyed by an antibiotic and pathogenic organisms can grow unchecked.
Rationale 4: Vaginal discharge is not a sign of antibiotic resistance.
Global Rationale: Antibiotics are unable to distinguish between host flora and pathogenic organisms. When an antibiotic kills the host's normal flora, additional nutrients and space are available for pathogenic microorganisms to grow unchecked. These new, secondary infections caused by antibiotic use are called superinfections, or suprainfections. The appearance of a new infection while receiving anti-infective therapy is highly suspicious of a superinfection. Signs and symptoms of superinfection commonly include diarrhea, bladder pain, painful urination, or abnormal vaginal discharges.