The nurse is researching a drug recently released on the market ...

[leilurhhh]

The nurse is researching a drug recently released on the market to determine what the median lethal dose (LD50) was in preclinical trials. The nurse recognizes that this number reflects which fact?
 
  1. The dose at which 50 of the research animals died
  2. A measurement of the potency of the drug
  3. The value of relative safety of the drug
  4. The dose that produced signs of toxicity in 50 of lab animals

Question 2

The nurse is educating a client who is participating in a drug study and describes the median toxicity dose as the dose that will produce toxicity in ____  of a group of clients.
 
  Fill in the blank with the appropriate word.

[Madisongo23]

Answer to Question 1

Correct Answer: 1
Rationale 1: The dose at which 50 of animals in the preclinical trials are killed is the median LD50 dose.
Rationale 2: A comparison of two drugs is done when defining the potency of a drug.
Rationale 3: Relative safety of dose is reflected in the therapeutic index.
Rationale 4: The dose at which signs of toxicity are seen in 50 of laboratory subjects is the median toxicity dose.
Global Rationale: The dose at which 50 of animals in the preclinical trials are killed is the median LD50 dose. A comparison of two drugs is done when defining the potency of a drug. Relative safety of dose is reflected in the therapeutic index. The dose at which signs of toxicity are seen in 50 of laboratory subjects is the median toxicity dose.

Answer to Question 2

Correct Answer: 50
Rationale: The median toxicity dose (TD50) is the dose that will produce a given toxicity in 50 of a group of clients.
Global Rationale: The median toxicity dose (TD50) is the dose that will produce a given toxicity in 50 of a group of clients.

[leilurhhh]

Thank you!

[Madisongo23]

Always glad to help...