Author Question: A prescriber has just ordered a medication for a patient and has ordered a larger dose than is ... (Read 106 times)

Jkov05 · **on:** Jul 23, 2018

A prescriber has just ordered a medication for a patient and has ordered a larger dose than is normally indicated. The patient questions the nurse and asks why the dose is so large. The nurse would be correct to explain that

a. the initial dose is sometimes higher to reach a therapeutic level more quickly.
b. an average effective dose is important to evaluate the response.
c. an initial dose will mean a half dose of subsequent medication.
d. all patients receive a high initial dose.

Question 2

Two nurses are discussing theories of drug-receptor interaction. One of the nurses states that which of the following statements is(are) true regarding the affinity of a drug and its receptor? (Select all that apply.)

a. Affinity and intrinsic activity are dependent properties.
b. Affinity refers to the strength of the attraction between a drug and its receptor.
c. Drugs with high affinity are strongly attracted to their receptors.
d. Drugs with low affinity are strongly attracted to their receptors.
e. The affinity of a drug for its receptors is reflected in its potency.

sierramartinez · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: A
The initial dose is sometimes given in a higher amount, a loading dose, to reach a therapeutic level in the blood more quickly, thus making the drug more effective.
An average effective dose is not used to evaluate the response to the medication.
The initial dose does not indicate that the subsequent doses will be one half of the initial dose.
All patients do not receive a high initial dose of a medication.

Answer to Question 2

ANS: B, C, E
Affinity does refer to the strength of the attraction between a drug and its receptor, drugs with high affinity are strongly attracted to their receptors, and the affinity of a drug for its receptors is reflected in its potency.
Affinity and intrinsic activity are independent properties.
Drugs with low affinity are weakly attracted to their receptors.