A patient is taking oral ketoconazole (Nizoral) for a systemic ...

[genevieve1028]

A patient is taking oral ketoconazole (Nizoral) for a systemic fungal infection. The nurse reviews the medication administration record and notes that the patient is also taking omeprazole (Prilosec) for reflux disease.
 
  What action should the nurse take?
  a. Administer the omeprazole 1 hour before the ketoconazole.
  b. Administer the omeprazole at least 2 hours after the ketoconazole.
  c. Confer with the prescriber about a potential hazardous interaction.
  d. The nurse should not administer omeprazole to a patient receiving ketoconazole.

Question 2

Metronidazole (Flagyl) is ordered for a patient being prepared for colorectal surgery. The nurse understands that the rationale for administration of metronidazole is that it
 
  a. inhibits the C. difficile toxin.
  b. can treat the fungal infection.
  c. serves as prophylaxis for infection.
  d. is a broad-spectrum antibiotic.

[alexanderhamilton]

Answer to Question 1

ANS: B
The nurse should administer the omeprazole at least 2 hours after the ketoconazole to prevent a drug-drug interaction. Drugs that reduce gastric acidity should be administered no sooner than 2 hours after ingestion of ketoconazole because they reduce absorption of the drug.
Drugs that reduce gastric acidity should be administered no sooner than 2 hours after ingestion of ketoconazole because they reduce absorption of the drug.
There is no need to confer with prescriber or refuse to administer the drugs as this is an appropriate drug combination.

Answer to Question 2

ANS: C
Metronidazole is used for prophylaxis in surgical procedures associated with a high risk of infection by anaerobes (colorectal surgery, abdominal surgery, vaginal surgery).
In this scenario, metronidazole is not given to inhibit the C. difficile toxin.
Metronidazole is not indicated for treatment a fungal infection, and nothing indicates that the patient has such an infection.
Metronidazole is not a broad-spectrum antibiotic.

[genevieve1028]

Thank you!

[alexanderhamilton]

Always glad to help...