Answer to Question 1
a, b
Answer to Question 2
D
Spironolactone should be avoided, because it is only a mild diuretic with dysfunctional kidneys.
Inderal, Aldomet and Apresoline all are antihypertensive agents and may be used. Although all classes of antihypertensive agents are effective in nephrosclerosis, angiotensin-converting enzyme (ACE) inhibitors and angiotensin-receptor blockers (ARBs) work best. As a rule, a diuretic also is used. In patients with advanced renal insufficiency, thiazide diuretics are ineffective; a loop diuretic should be used.