A nurse is obtaining a drug history from a patient about to ...

[SO00]

A nurse is obtaining a drug history from a patient about to receive sulfadiazine. The nurse learns that the patient takes warfarin, glipizide, and a thiazide diuretic. Based on this assessment, the nurse will expect the provider to:
 
  a. change the antibiotic to TMP/SMZ.
  b. increase the dose of the glipizide.
  c. monitor the patient's electrolytes closely.
  d. monitor the patient's coagulation levels.

Question 2

A researcher working for a pharmaceutical company is providing orientation to a new nurse researcher. The researcher determines that further education is needed when the nurse states that
 
  a. preclinical testing takes place in animals.
  b. clinical testing phase 1 involves normal volunteers.
  c. clinical testing phase 2 involves normal volunteers.
  d. clinical testing phase 3 involves patients.

[amy.lauersdorf90]

Answer to Question 1

D
Sulfonamides interact with several drugs and through metabolism-related interactions can inten-sify the effects of warfarin. Patients taking both should be monitored closely for bleeding ten-dencies. Changing to the combination product will not help, because sulfonamides are still present. Sulfonamides intensify glipizide levels, so this drug may actually need to be reduced. Trimethoprim, not sulfonamides, raises potassium levels.

Answer to Question 2

C
Clinical testing phase 2 involves patients, not normal volunteers, therefore further education is required.
Preclinical testing does take place in animals, therefore no further education is necessary.
Clinical testing phase 1 does involve normal volunteers, therefore no further education is needed.
Clinical testing phase 3 involves patients, therefore no further education is required.

DIF: Cognitive Level: Comprehension REF: p. 17
TOP: Nursing Process: Evaluation
MSC: NCLEX Client Needs Category: Physiological Integrity: Pharmacological and Parenteral Therapies

[SO00]

Wow, this really help

[kjohnson]

Excellent