Which are therapeutic uses for verapamil? (Select all that ...

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Which are therapeutic uses for verapamil? (Select all that apply.)
 
  a. Angina of effort
  b. Cardiac dysrhythmias
  c. Essential hypertension
  d. Sick sinus syndrome
  e. Suppression of preterm labor

Question 2

A patient who has been using secobarbital for several months to treat insomnia tells the nurse that the prescriber has said the prescription will be changed to temazepam Restoril because it is safer. The patient asks why this agent is safer.
 
  The nurse is correct in telling the patient that temazepam: a. does not depress the central nervous sys-tem.
  b. shows no respiratory depression, even in toxic doses.
  c. mimics the actions of a central nervous system inhibitory neurotransmitter.
  d. potentiates endogenous gam-ma-aminobutyric acid (GABA) producing a finite CNS depression.

[kxciann]

Answer to Question 1

A, B, C
Verapamil is used to treat both vasospastic angina and angina of effort. It slows the ventricular rate in patients with atrial flutter, atrial fibrillation, and paroxysmal supraventricular tachycardia. It is a first-line drug for the treatment of essential hypertension. It is contraindicated in patients with sick sinus syndrome. Nifedipine has investigational uses in suppressing preterm labor.

Answer to Question 2

D
Benzodiazepines potentiate the actions of GABA, and because the amount of GABA in the CNS is finite, these drugs' depressive effect on the CNS is limited. Benzodiazepines depress the CNS but not to the extent that barbiturates do. Benzodiazepines are weak respiratory depressants at therapeutic doses and moderate respiratory depressants at toxic doses. Barbiturates mimic GA-BA; therefore, because they produce CNS depression, this effect is limited only by the amount of barbiturate administered.

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Thanks for the timely response, appreciate it

[Dominic]

TYSM