Author Question: The nurse is caring for a patient diagnosed with Parkinson's disease who has been prescribed an ... (Read 13 times)

kfurse · **on:** Jul 23, 2018

The nurse is caring for a patient diagnosed with Parkinson's disease who has been prescribed an anticholinergic drug. When are anticholinergic drugs usually added to the therapeutic regimen?

A) When symptoms increase
B) Sporadically to reduce development of toleration to levodopa
C) When levodopa does not elicit a therapeutic response
D) During the end stage of the disease process

Question 2

A patient newly diagnosed with chronic myelocytic leukemia () has been prescribed treatment with imatinib. The patient asks the nurse how imatinib works. What would be the nurse's best response?

A) imatinib alkylates cellular DNA.
B) imatinib inhibits folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication.
C) imatinib binds to DNA and inhibits DNA synthesis in susceptible cells, causing cell death.
D) imatinib inhibits the enzyme created by the Philadelphia chromosome abnormality in CML.

bhavsar · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

C
Feedback:
Although anticholinergics are not as effective as levodopa in the treatment of advancing cases of the disease, they may be useful as adjunctive therapies and for patients who no longer respond to levodopa. They are not withheld until symptoms advance or end-stage symptoms occur and they are not given sporadically.

Answer to Question 2

D
Feedback:
Imatinib is a tyrosine kinase inhibitor that selectively inhibits the Bcr-Abl tyrosine kinase created by the Philadelphia chromosome abnormality in CML and some tumor cells present in gastrointestinal stromal tumor (GIST); blocking this enzyme inhibits proliferation and induces cell division. Alkylating agents alkylate cellular DNA; antimetabolites inhibit folic acid reductase, leading to inhibition of deoxyribonucleic acid (DNA) synthesis and inhibition of cellular replication; and antineoplastic antibiotics bind to DNA and inhibit DNA synthesis in susceptible cells, causing cell death.