A 70-year-old female patient has just been diagnosed with ...

[folubunmi]

A 70-year-old female patient has just been diagnosed with Alzheimer's disease. What cholinergic drug is used for the treatment of Alzheimer's disease?
 
  A) Bethanechol (Duvoid)
  B) Neostigmine (Prostigmin)
  C) Donepezil (Aricept)
  D) Edrophonium (Enlon, Reversol)

Question 2

A nurse is providing teaching to a group of patients who are beginning drug therapy for acquired immunodeficiency syndrome (AIDS). What should be included in her instructions to the group?
 
  A) Take your medications as directed. Poisoning occurs with overdosage causing damage to more than one body system.
  B) Renal injury results from first-pass effect when the drug is excreted from the system.
  C) A blood dyscrasia due to drug therapy can be serious. Call us if your skin looks yellowish or you experience itching.
  D) Most drugs are metabolized in the liver and the first indication of damage is dark red papules, which should be reported immediately.

[zacnyjessica]

Answer to Question 1

C
Feedback:
Currently, there are four reversible indirect-acting cholinergic agonists available to slow the progression of this disease. These include tacrine (Cognex), galantamine (Razadyne), rivastigmine (Exelon), and donepezil (Aricept). Edrophonium (Enlon, Reversol) is used to diagnose myasthenia gravis; neostigmine is used for the diagnosis and management of myasthenia gravis; and bethanechol is used to treat neurogenic bladder.

Answer to Question 2

A
Feedback:
Poisoning resulting from overdosage can lead to the potential for fatal reactions when more than one body system is affected. Liver, not kidney, injury can be caused by the first-pass effect and can cause the skin to have a yellow appearance. Most drugs are metabolized in the liver but liver damage causes jaundice, manifested as a yellow tinge to the skin and sclera. Dark red papules appearing on limbs are characteristic of Stevens-Johnson syndrome, a potentially fatal erythema multiforme exudativum, which should be reported but is not due to liver damage.

[folubunmi]

Thank you!

[zacnyjessica]

Always glad to help...