A patient who has long abused alcohol is being treated with ...

[mydiamond]

A patient who has long abused alcohol is being treated with disulfiram (Antabuse). The patient currently takes phenytoin (Dilantin) for an underlying seizure disorder.
 
  Based on the interaction of these two medications, what will need to be adjusted in the medication administration? A) The patient will require more frequent administration of disulfiram (Antabuse).
  B) The patient will require a larger dose of disulfiram (Antabuse).
  C) The patient will require a reduced dose of phenytoin (Dilantin).
  D) The patient will require phenytoin (Dilantin) to be administered twice daily.

Question 2

A patient has been suffering from repeated sinus infections and is diagnosed with allergic rhinitis. The patient is prescribed a first-generation H1 receptor antagonist. What is one of the effects of this medication?
 
  A) It depletes norepinephrine and serotonin.
  B) It decreases capillary permeability.
  C) It catalyzes the enzymatic oxidation of uric acid.
  D) It raises the seizure threshold by impairing vitamin D.

[Brummell1998]

Answer to Question 1

C
Feedback:
The patient will require a reduced dose of phenytoin (Dilantin) because disulfiram interferes with the metabolism of phenytoin. The patient will not require more frequent administration of disulfiram. The patient will not require a larger dose of disulfiram. The patient will not require increased administration of phenytoin.

Answer to Question 2

B
Feedback:
Decreased capillary permeability is among the effects of first-generation drugs. H1 receptor antagonists do not affect vitamin D, uric acid, or neurotransmitters.