Which of the following is an example of cooperativity?
A) the binding of an end product of a metabolic pathway to the first enzyme that acts in the pathway
B) one enzyme in a metabolic pathway passing its product to act as a substrate for the next enzyme in the pathway
C) a molecule binding at one unit of a tetramer, allowing faster binding at each of the other three
D) the effect of increasing temperature on the rate of an enzymatic reaction
E) binding of an ATP molecule along with one of the substrate molecules in an active site
The fraction of ligand-binding sites occupied, θ
5-25 Induced fit in the binding of an antigen to IgG
Macromolecules can have distinct binding sites for multiple ligands
Plasma protein binding and drug availability: (a) drug exists in a free state or bound to plasma pro
Two classical models for the cooperative ligand binding by hemoglobin
Antigen binding by an Fab fragment