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In 1864, the first barbiturate (barbituric acid) was synthesized.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.
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You should not take more than 1,000 mg of vitamin E per day. Doses above this amount increase the risk of bleeding problems that can lead to a stroke.