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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
There can actually be a 25-hour time difference between certain locations in the world. The International Date Line passes between the islands of Samoa and American Samoa. It is not a straight line, but "zig-zags" around various island chains. Therefore, Samoa and nearby islands have one date, while American Samoa and nearby islands are one day behind. Daylight saving time is used in some islands, but not in others—further shifting the hours out of sync with natural time.
Before a vaccine is licensed in the USA, the Food and Drug Administration (FDA) reviews it for safety and effectiveness. The CDC then reviews all studies again, as well as the American Academy of Pediatrics and the American Academy of Family Physicians. Every lot of vaccine is tested before administration to the public, and the FDA regularly inspects vaccine manufacturers' facilities.
Barbituric acid, the base material of barbiturates, was first synthesized in 1863 by Adolph von Bayer. His company later went on to synthesize aspirin for the first time, and Bayer aspirin is still a popular brand today.
In the United States, there is a birth every 8 seconds, according to the U.S. Census Bureau's Population Clock.
![A full-term pregnancy. Image illustrates position of the fetus and the structures associated with pr](https://biology-forums.com/gallery/47/medium_14755_28_08_12_1_48_05_82531516.jpeg)
![A histologic slide showing the sponge-like architecture of a patient with Creutzfeldt-Jakob Disease.](https://biology-forums.com/gallery/29/medium_548020_11_05_17_3_50_42_29047222.jpeg)
![Effleurage between the metatarsals using the thumb or fingers. Slide between the metatarsals oneby- ...](https://biology-forums.com/gallery/33/medium_380798_23_08_17_1_04_35_3308410.jpeg)