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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
In 1864, the first barbiturate (barbituric acid) was synthesized.
Automated pill dispensing systems have alarms to alert patients when the correct dosing time has arrived. Most systems work with many varieties of medications, so patients who are taking a variety of drugs can still be in control of their dose regimen.
Your skin wrinkles if you stay in the bathtub a long time because the outermost layer of skin (which consists of dead keratin) swells when it absorbs water. It is tightly attached to the skin below it, so it compensates for the increased area by wrinkling. This happens to the hands and feet because they have the thickest layer of dead keratin cells.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.