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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
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The most dangerous mercury compound, dimethyl mercury, is so toxic that even a few microliters spilled on the skin can cause death. Mercury has been shown to accumulate in higher amounts in the following types of fish than other types: swordfish, shark, mackerel, tilefish, crab, and tuna.
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Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing for mass cultivation and purification from bacterial cultures.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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It is difficult to obtain enough calcium without consuming milk or other dairy foods.