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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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Addicts to opiates often avoid treatment because they are afraid of withdrawal. Though unpleasant, with proper management, withdrawal is rarely fatal and passes relatively quickly.
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The FDA recognizes 118 routes of administration.