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Acetaminophen (Tylenol) in overdose can seriously damage the liver. It should never be taken by people who use alcohol heavily; it can result in severe liver damage and even a condition requiring a liver transplant.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.
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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.