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There are major differences in the metabolism of morphine and the illegal drug heroin. Morphine mostly produces its CNS effects through m-receptors, and at k- and d-receptors. Heroin has a slight affinity for opiate receptors. Most of its actions are due to metabolism to active metabolites (6-acetylmorphine, morphine, and morphine-6-glucuronide).
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There are 20 feet of blood vessels in each square inch of human skin.
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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
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Illicit drug use costs the United States approximately $181 billion every year.
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.