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Chronic necrotizing aspergillosis has a slowly progressive process that, unlike invasive aspergillosis, does not spread to other organ systems or the blood vessels. It most often affects middle-aged and elderly individuals, spreading to surrounding tissue in the lungs. The disease often does not respond to conventionally successful treatments, and requires individualized therapies in order to keep it from becoming life-threatening.
Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
There are approximately 3 million unintended pregnancies in the United States each year.
Though the United States has largely rejected the metric system, it is used for currency, as in 100 pennies = 1 dollar. Previously, the British currency system was used, with measurements such as 12 pence to the shilling, and 20 shillings to the pound.
Human kidneys will clean about 1 million gallons of blood in an average lifetime.
![Aurora australis observed from the Space Shuttle Discovery, on STS-39, May 1991 (orbital altitude: 2](https://biology-forums.com/gallery/47/medium_12359_17_05_12_12_49_27.jpeg)
![Alexander Fleming photographed in his lab where he observed the natural competition between a fungus](https://biology-forums.com/gallery/47/medium_14755_11_11_12_7_20_13_100452376.jpeg)