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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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Illicit drug use costs the United States approximately $181 billion every year.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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More than 4.4billion prescriptions were dispensed within the United States in 2016.