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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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When intravenous medications are involved in adverse drug events, their harmful effects may occur more rapidly, and be more severe than errors with oral medications. This is due to the direct administration into the bloodstream.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.