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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
In 2012, nearly 24 milliion Americans, aged 12 and older, had abused an illicit drug, according to the National Institute on Drug Abuse (NIDA).
In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.
![In 2008, the U.S. economy suffered a gaping wound as several trillion dollars were ripped out of it.](https://biology-forums.com/gallery/47/medium_262797_12_08_15_1_33_47_22176335.png)
![A passenger train crosses Stony Creek Bridge in the Rocky Mountains in 1878. Railroads were importan](https://biology-forums.com/gallery/47/medium_27_24_08_15_1_27_03_22389406.jpeg)