Describe the monoamine hypothesis of depression and discuss ...

[saliriagwu]

Describe the monoamine hypothesis of depression and discuss evidence that supports this hypothesis.
 
  What will be an ideal response?

Question 2

In the chapter prologue on addiction, what factor induced John to restart his heroin addiction?
 
  A) John smoked some marijuana and drank some alcohol, which led him back into heroin use.
  B) The stress of losing his job led to drug relapse.
  C) John saw a poster on drug paraphernalia and experienced a very strong drug craving.
  D) John was reintroduced to heroin while in prison.
  E) All of the above are correct.

[LVPMS]

Answer to Question 1

Answer: Depression (without mania) reflects profound changes in mood, appetite, movement, and sleep. The monoamine hypothesis argues that depression reflects a reduced level of activity of the monoamine transmitters, specifically norepinephrine (NE) and serotonin (5-HT). A variety of treatments exist for unipolar depression (MAOI, tricyclics, serotonin reuptake inhibitors, ECT, and sleep deprivation). The tricyclic drugs block the reuptake of NE and 5-HT, while the serotonin reuptake inhibitors block only serotonin reuptake (resulting in more serotonin). The tryptophan deletion procedure lowers brain serotonin levels and can reinstate depression.

Answer to Question 2

Answer: C
Rationale: In the chapter prologue on addiction, John saw a poster on drug paraphernalia and experienced a very strong drug craving which led him to relapse.

[saliriagwu]

Thanks for the timely response, appreciate it

[connor417]

Gracias!