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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.

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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.

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Urine turns bright yellow if larger than normal amounts of certain substances are consumed; one of these substances is asparagus.

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Approximately 15–25% of recognized pregnancies end in miscarriage. However, many miscarriages often occur before a woman even knows she is pregnant.

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In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

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