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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.

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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.

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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.

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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.

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Before a vaccine is licensed in the USA, the Food and Drug Administration (FDA) reviews it for safety and effectiveness. The CDC then reviews all studies again, as well as the American Academy of Pediatrics and the American Academy of Family Physicians. Every lot of vaccine is tested before administration to the public, and the FDA regularly inspects vaccine manufacturers' facilities.

Stages of a Neurospora cross Stages of a Neurospora cross
Internal structures of main sequence stars, convection zones with arrowed cycles and radiative zones Internal structures of main sequence stars, convection zones with arrowed cycles and radiative zones
Structures of the internal nose, mouth, and throat. Structures of the internal nose, mouth, and throat.
A radiator may be either a down-flow or a cross-flow type. A radiator may be either a down-flow or a cross-flow type.
Internal Defenses Internal Defenses
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