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Author Question: Explain the relationship between the hypocretin system and the symptoms of narcolepsy. What will ... (Read 47 times)

roselinechinyere27m

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on: Jun 22, 2018
Explain the relationship between the hypocretin system and the symptoms of narcolepsy.
 
  What will be an ideal response?

Question 2

Compare and contrast the neural systems and relevant transmitters that control slow-wave sleep.
 
  What will be an ideal response?


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kiamars2010

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Reply #1 on: Jun 22, 2018
Answer to Question 1

Answer: Certain aspects of REM sleep (paralysis, dreaming) appear to intrude into the daytime hours in a person with narcolepsy. Sleep attack is an overwhelming urge to sleep for a few minutes. During cataplexy, a person has paralysis while conscious, whereas during sleep, paralysis occurs just before or just after sleep. Hypnagogic hallucinations are dreams that occur during sleep paralysis. Narcolepsy involves damage to the brain hypocretin system.

Answer to Question 2

Answer: Slow-wave sleep is produced by activity of neurons within the ventrolateral preoptic area (vlPOA) that act by inhibition of neural systems that promote wakefulness. The vlPOA secretes GABA, which in turn inhibits transmitter systems that are key to arousal and wakefulness. These include norepinephrine within the locus coeruleus, histamine in the tuberomammillary nucleus, and serotonin within the raphe nuclei. Adenosine may promote sleep by GABA-mediated inactivation of acetylcholine neurons that promote arousal. Orexin (hypocretin) neurons promote wakefulness.


roselinechinyere27m

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Reply 2 on: Jun 22, 2018
Thanks for the timely response, appreciate it

adammoses97

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Reply 3 on: Yesterday
Excellent

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