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In 1864, the first barbiturate (barbituric acid) was synthesized.
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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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ACTH levels are normally highest in the early morning (between 6 and 8 A.M.) and lowest in the evening (between 6 and 11 P.M.). Therefore, a doctor who suspects abnormal levels looks for low ACTH in the morning and high ACTH in the evening.
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Malaria was not eliminated in the United States until 1951. The term eliminated means that no new cases arise in a country for 3 years.
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Intradermal injections are somewhat difficult to correctly administer because the skin layers are so thin that it is easy to accidentally punch through to the deeper subcutaneous layer.