Answer to Question 1
The likelihood that the drug will be effective would be low, thus, potentially lengthening the person's time of misery or dysfunction by several weeks or months before the appropriate medication is prescribed. Also, tricyclics and SSRIs generally produce more uncomfortable side effects than lithium and may precipitate a manic episode in the bipolar individual. On the other hand, because of lithium's very low therapeutic index, a unipolar patient given lithium would have to undergo expensive and unnecessary blood tests to make sure they don't overdose.
Answer to Question 2
d