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Approximately 500,000 babies are born each year in the United States to teenage mothers.

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In 1864, the first barbiturate (barbituric acid) was synthesized.

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Signs of depression include feeling sad most of the time for 2 weeks or longer; loss of interest in things normally enjoyed; lack of energy; sleep and appetite disturbances; weight changes; feelings of hopelessness, helplessness, or worthlessness; an inability to make decisions; and thoughts of death and suicide.

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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.

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Ether was used widely for surgeries but became less popular because of its flammability and its tendency to cause vomiting. In England, it was quickly replaced by chloroform, but this agent caused many deaths and lost popularity.

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