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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.

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The strongest synthetic topical retinoid drug available, tazarotene, is used to treat sun-damaged skin, acne, and psoriasis.

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The people with the highest levels of LDL are Mexican American males and non-Hispanic black females.

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Vital signs (blood pressure, temperature, pulse rate, respiration rate) should be taken before any drug administration. Patients should be informed not to use tobacco or caffeine at least 30 minutes before their appointment.

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Thyroid conditions cause a higher risk of fibromyalgia and chronic fatigue syndrome.

Epiphyseal Usually occurs through the growth plate where the matrix is undergoing calcification and Epiphyseal Usually occurs through the growth plate where the matrix is undergoing calcification and
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