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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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There are 60,000 miles of blood vessels in every adult human.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.