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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.
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Illness; diuretics; laxative abuse; hot weather; exercise; sweating; caffeine; alcoholic beverages; starvation diets; inadequate carbohydrate consumption; and diets high in protein, salt, or fiber can cause people to become dehydrated.
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Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
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Long-term mental and physical effects from substance abuse include: paranoia, psychosis, immune deficiencies, and organ damage.
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Colchicine is a highly poisonous alkaloid originally extracted from a type of saffron plant that is used mainly to treat gout.