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Throughout history, plants containing cardiac steroids have been used as heart drugs and as poisons (e.g., in arrows used in combat), emetics, and diuretics.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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After a vasectomy, it takes about 12 ejaculations to clear out sperm that were already beyond the blocked area.
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Persons who overdose with cardiac glycosides have a better chance of overall survival if they can survive the first 24 hours after the overdose.