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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Alcohol acts as a diuretic. Eight ounces of water is needed to metabolize just 1 ounce of alcohol.
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The average adult has about 21 square feet of skin.