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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
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About 100 new prescription or over-the-counter drugs come into the U.S. market every year.
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In 1864, the first barbiturate (barbituric acid) was synthesized.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.