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The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.
Cancer has been around as long as humankind, but only in the second half of the twentieth century did the number of cancer cases explode.
Inotropic therapy does not have a role in the treatment of most heart failure patients. These drugs can make patients feel and function better but usually do not lengthen the predicted length of their lives.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.