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The FDA recognizes 118 routes of administration.
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The use of salicylates dates back 2,500 years to Hippocrates's recommendation of willow bark (from which a salicylate is derived) as an aid to the pains of childbirth. However, overdosage of salicylates can harm body fluids, electrolytes, the CNS, the GI tract, the ears, the lungs, the blood, the liver, and the kidneys and cause coma or death.
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After 5 years of being diagnosed with rheumatoid arthritis, one every three patients will no longer be able to work.
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In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.