Question 1
Loss of
Xist gene due to mutation leads to defects in which epigenetic process?
◦ RNAi
◦ X-inactivation
◦ genomic imprinting
◦ position effect variegation
◦ methylation of CpG islands
Question 2
Many types of cancer are known to overexpress the receptor protein tyrosine kinase. Which molecular technique can be used to reduce expression of tyrosine kinase in cell culture?
◦ PCR
◦ DNAse sensitivity assay
◦ RNAi
◦ southern blotting
◦ western blotting