Question 1
Shotgun sequencing requires all of the following except?
◦ a computer
◦ a genetic map
◦ a DNA sequencing technology
◦ software capable of comparing DNA sequence
◦ many overlapping DNA sequences
Question 2
Subtelomeres are blocks of homologous DNA sequences close to the ends of chromosomes. When sequences of chromosomes 4q and 10q subtelomeres were analyzed from a world-wide population, only seventeen 4q haplotypes and and eight 10q haplotypes were found among African, European, and Asian groups, making these the least diverse subtelomeres shared by these ethnic groups. Which conclusion do these data support?
◦ finding that few or no interchromosomal exchanges can occur among these chromosomes
◦ a conclusion that all haplotypes were present before the human population migrated from Africa
◦ reporting that haplotype polymorphism shows no response to natural selection
◦ humans have made multiple migrations out of Africa
◦ a conclusion that assigning chromosomal origin is only possible in a population with the same ethnic origin
Homologous Chromosomes
Mitosis Chromosomes
Crossing over during meiosis leads to allele combinations in sex cells that are not present in the p
pair of homologous chromosomes
Chuck Close, Stanley II, detail. 1980–81.
The Holliday model for homologous recombination