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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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The first-known contraceptive was crocodile dung, used in Egypt in 2000 BC. Condoms were also reportedly used, made of animal bladders or intestines.
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The horizontal fraction bar was introduced by the Arabs.
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There are approximately 3 million unintended pregnancies in the United States each year.