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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.
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Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
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The people with the highest levels of LDL are Mexican American males and non-Hispanic black females.